TV 00s

Which is NOT a Seth MacFarlane animated series?

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On what network did the show "Kyle XY" premiere in 2006?
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Who is left at the altar in the TV series "One Tree Hill"?
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Which is a sci-fi themed TV series?
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Which of these popular TV characters appeared in "Lost"?
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Which MTV personality of the early 2000's appeared in a few episodes of "Melrose Place"?
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